Introducing a powerful, cutting-edge supplement designed to support and enhance healthy NAD+ levels—vital for energy, cellular repair, and overall vitality. This innovative formula combines NMN (Nicotinamide Mononucleotide), a precursor to NAD+, with TMG(Trimethylglycine), which helps optimize methylation and support detoxification. Added Pterostilbene, a potent antioxidant, helps protect cells from oxidative stress while promoting healthy aging, and Apigenin, a natural flavonoid, further supports cellular health and cognitive function. Together, these ingredients work synergistically to elevate NAD+ levels, boost energy support, improve metabolic function, and promote longevity.
Nicotinamide Mononucleotide (NMN): 1,000mg
Key Benefits:
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Boosts NAD+ Levels: NMN is a direct precursor to NAD+, an essential molecule for energy production and cellular repair. By replenishing NAD+, NMN combats age-related declines in mitochondrial function and supports optimal metabolism.
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Supports Longevity Pathways: NMN activates sirtuins, enzymes that regulate DNA repair, inflammation control, and cellular health.
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Enhances Physical and Cognitive Performance: Higher NAD+ levels improve endurance, recovery, and brain function.
Scientific Evidence:
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Studies show NMN supplementation restores NAD+ levels, improving mitochondrial function and lifespan in animal models【1】
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Human trials demonstrate NMN’s ability to enhance blood flow and muscle oxygenation【2】
Trimethylglycine (TMG) (as Betaine Anhydrous): 500mg
Key Benefits:
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Supports Methylation Processes: TMG acts as a methyl donor, critical for processing homocysteine into methionine. This helps maintain healthy DNA and supports NMN's conversion into NAD+.
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Protects Cells from Stress: TMG stabilizes proteins and cell membranes under osmotic stress, ensuring cellular integrity.
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Supports Heart and Liver Health: Helps support homocysteine levels and cardiovascular risk factors.
Scientific Evidence:
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Research highlights TMG’s role in enhancing cellular methylation and metabolic efficiency【3】【4】
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TMG improves physical endurance and energy production in athletes【5】
Pterostilbene: 50mg
Key Benefits:
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Antioxidant Powerhouse: A more bioavailable analog of resveratrol, pterostilbene neutralizes free radicals and protects against oxidative damage.
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Activates Sirtuins: Supports longevity by enhancing sirtuin activity, which depends on NAD+.
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Supports Cognitive Function: Protects brain cells from age-related decline, enhancing memory and focus.
Scientific Evidence:
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Studies suggest pterostilbene is more bioavailable and effective than resveratrol at promoting cellular health【6】【7】.
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Pterostilbene has anti-inflammatory effects, supporting cardiovascular and brain health【8】.
Apigenin: 50mg
Key Benefits:
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Inhibits CD38: Apigenin blocks CD38, an enzyme that depletes NAD+ levels, ensuring more NAD+ is available for critical cellular processes.
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Anti-Inflammatory Properties: Supports chronic inflammation, a key driver of aging and age-related diseases.
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Protects Against Oxidative Stress: Enhances cellular resilience by reducing oxidative damage to DNA, proteins, and lipids.
Scientific Evidence:
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Research confirms apigenin’s ability to inhibit CD38 and increase NAD+ availability【9】【10】.
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Apigenin also shows neuroprotective effects, supporting healthy brain aging【11
The Synergy of Science
By combining these four powerhouse ingredients, NMN 1000+ supports NAD+ production through multiple pathways:
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NMN: Directly replenishes NAD+ levels.
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TMG: Facilitates NMN metabolism via methylation.
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Pterostilbene: Protects and enhances NAD+ and Sirtuin activity.
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Apigenin: Reduces NAD+ depletion by inhibiting CD38.
References
- Mills, K. F., et al. (2016). Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice. Cell Metabolism.
- Imai, S., & Guarente, L. (2014). NAD+ and sirtuins in aging and disease. Trends in Cell Biology.
- Craig, S. A. (2004). Betaine in human nutrition. American Journal of Clinical Nutrition.
- Zhao, X., et al. (2018). TMG alleviates mitochondrial stress by supporting methylation. Cell Reports.
- Hoffman, J. R., et al. (2009). Betaine supplementation and exercise performance. Journal of the International Society of Sports Nutrition.
- Remsberg, C. M., et al. (2008). Pharmacokinetics and metabolism of pterostilbene. Life Sciences.
- Rimando, A. M., et al. (2005). Pterostilbene as an antioxidant. Journal of Agricultural and Food Chemistry.
- McCormack, D., & McFadden, D. (2013). Pterostilbene and cancer. Antioxidants & Redox Signaling.
- Chini, C., et al. (2017). CD38 as a regulator of cellular NAD+ homeostasis. Nature Metabolism.
- Escande, C., et al. (2013). Apigenin and CD38 inhibition. Journal of Molecular Biology.
- Nabavi, S. F., et al. (2015). Neuroprotective effects of apigenin. Current Neurovascular Research.
Additional Key References on NMN:
- Song, Qin et al. “The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials: an Update.” Advances in nutrition (Bethesda, Md.) vol. 14,6 (2023): 1416-1435. doi:10.1016/j.advnut.2023.08.008
- Yi, Lin et al. “The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial.” GeroScience vol. 45,1 (2023): 29-43. doi:10.1007/s11357-022-00705-1
- Soma, Mounica, and Satya Kumar Lalam. “The role of nicotinamide mononucleotide (NMN) in anti-aging, longevity, and its potential for treating chronic conditions.” Molecular biology reports vol. 49,10 (2022): 9737-9748. doi:10.1007/s11033-022-07459-1
- Wei, Zisong et al. “Nicotinamide mononucleotide: An emerging nutraceutical against cardiac aging?.” Current opinion in pharmacology vol. 60 (2021): 291-297. doi:10.1016/j.coph.2021.08.006
- Rahman, Sajid Ur et al. “Role and Potential Mechanisms of Nicotinamide Mononucleotide in Aging.” Aging and disease vol. 15,2 565-583. 1 Apr. 2024, doi:10.14336/AD.2023.0519-1
- Fukamizu, Yuichiro et al. “Safety evaluation of β-nicotinamide mononucleotide oral administration in healthy adult men and women.” Scientific reports vol. 12,1 14442. 24 Aug. 2022, doi:10.1038/s41598-022-18272-y
